Southampton remain without star striker Charlie Austin having missed the last five weeks due to a dislocated shoulder, and is joined by left-back Matt Targett who is sidelined with a hamstring injury.
Shane Long is set to be recalled in the starting eleven, and will lead the attack up-front alongside Nathan Redmond and Dusan Tadic.
As for the hosts, midfielders Johanna Gudmundsson and Scott Arfield are doubts who are both suffering with hamstring injuries.
On the plus, defender Jon Flanagan is nearing a return to full match fitness following a knee injury, and striker George Boyd is fully fit having recovered from a knock.
Claude Piel’s Southampton side will be looking to end their three-match losing streak in the Premier League, when they face Burnley away at Turf Moor on Saturday afternoon.
The Saints have suffered back-to-back home defeats to Tottenham and West Brom, and their recent 3-0 loss to the Toffees at Goodison earlier this month.
Despite this, the visitors sit comfortably in 10th place and they’ll be in high spirits following their 1-0 home win over Liverpool during the EFL Cup semi-final first leg on Wednesday night, thanks to a first half strike from Nathan Redmond.
Meanwhile, Burnley head into the home clash one point behind their opponents in 12th, following a 2-1 defeat away to Manchester City last week.
However, on home soil the Clarets have won three straight matches, including a four goal thumping over Sunderland on New Year’s Eve, with forward Andre Gray bagging a hat-trick.
When both sides met back in October, it was Southampton that took all three points thanks to a Charlie Austin double and Nathan Redmond goal in the 3-1 win at Saint Mary’s.
Heaton (GK), Ward, Mee, Lowton, Keane, Kightly, Hendrick, Boyd, Barton, Barnes, Gray
Forster (GK), McQueen, Yoshida, Fonte, Soares, Ward-Prowse, Clasie, Romeu, Redmond, Tadic, Long