Atletico winger Yannick Carrasco has been ruled out of action for the weekend clash with a foot injury, and forward Kevin Gamerio also remains a doubt for the hosts suffering with flu.
Fernando Torres is set to keep his place upfront for Los Rojiblancos, alongside goal-scorers Antoine Griezmann and Saul Niguez who were on target in the win over Eibar last week.
Meanwhile, Betis have been dealt a double blow with midfielders Petros and Bruno Gonzalez unable to make the trip to the capital through suspension.
Ruben Castro will spearhead the attack for the visiting side, and was amongst the scorers during the 2-0 home win over Leganes last weekend.
Atletico Madrid looks to extend their two-match winning streak in La Liga this weekend, when they take on Real Betis at the Estadio Vicente Calderon on Saturday afternoon.
Currently, Diego Simeone’s men sit fourth in the table following their 2-0 win over Eibar last weekend, trailing four points behind third-placed and defending champions Barcelona.
A victory for Atleti will make it six wins from seven in all competitions and they’ll be overwhelming favourites to pick up all three points on Saturday.
As for Real Betis, they come into the match following a 2-0 victory over strugglers Leganes last Sunday at the Benito Villamarín Stadium; making it back-to-back home victories.
However, Los Verdiblancos have struggled for form away from home with four defeats in their last five matches on their travels.
Furthermore, Betis have a horrid record against their weekend opponents having lost their last five meetings against Atletico, including a heavy 5-1 loss at the Calderon last season.
Moya (GK), Luis, Godin, Vrsaljko, Savic, Niguez, Koke, Gimenez, Gabi, Griezmann, Torres
Adan (GK), Carlos, Pezzella, Durmisi, Gonzalez, Navarro, Ceballos, dos Santos, Martin, Castro, Sanabria