Competition: Premier League Date: Wednesday 14th December 2016 Venue: Selhurst Park Kick-Off: 20:00 GMT
Crystal Palace are without Jason Puncheon, who serves a one-match ban, and Yohan Cabye is likely to come into the midfield as a result.
Martin Kelly could retain his spot at right-back with James Tomkins being a doubt, whilst Pape Soaure, Connor Wickham, Jonathan Benteke and Steve Mandanda remain sidelined.
Manchester United lost Henrikh Mkhitaryan to injury over the weekend and he joins Chris Smalling on the sidelines.
With Antonio Valencia suspended and Luke Shaw lacking fitness, changes in defence are likely and Eric Bailly could earn a recall.
Crystal Palace remain unbeaten in their last two Premier League matches but their defending is abysmal, although fortunately they’ve also managed to find the net regularly. Overall though, five goals a game in their last seven matches will be a concern.
Manchester United gave their chances of a top-four finish a boost at the weekend by overcoming Tottenham and they secured back-to-back wins in all competitions for the first-time since September as a result. They’ll be full of confidence but it will certainly be a tricky encounter.
United have struggled in their trips to Selhurst Park in recent years and the threat posed by Wilfried Zaha and Christian Benteke could once again expose the defensive frailties of Jose Mourinho’s side.
Hennessey, Kelly, Dann, Delaney, Ward, Ledley, McArthur, Townsend, Cabaye, Zaha, Benteke
De Gea, Young, Bailly, Jones, Darmian, Herrera, Carrick, Lingard, Pogba, Martial, Ibrahimovic
Man Utd are undefeated in their last 11 matches against Crystal Palace in all competitions.
United are unbeaten in their last six Premier League matches.