Lazio are likely to be without forward Keita ahead of Saturday night’s league encounter due to a knee injury, whilst midfielder Danilo Cataldi is unavailable through suspension.
Sergej Milinkovic-Savic is set to start in the midfield and will lead the attack alongside Dutchmen Ricardo Kishna and the in-form Ciro Immobile.
Meanwhile, the hosts are likely to name an unchanged side from their win over Torino last weekend with duo Luis Muriel and Fabio Quagliarella starting up-front for the Blucerchiati.
On the injury front, striker Domenico Berardi is close to a return following a knee injury, but remains sidelined for the next 2-3 weeks.
Sampdoria look to make it five straight home wins this weekend, when they play host to Lazio at the Stadio Luigi Ferraris on Saturday evening.
Currently, Blucerchiati sit ninth place in Serie A following their 2-0 win over Torino last week, which included goals from Edgar Barreto and substitute Patrik Schick.
Head coach Marco Giampaolo will be pleased with his side’s performances of late, who remain unbeaten in their last six league matches and they’ll be aiming to push further up the table in pursuit of Europa League qualification.
In contrast, visitors Lazio’s come into the weekend still hurting, following their 2-0 derby day defeat to Roma last weekend, involving a sending off for substitute Danilo Cataldi.
However, Simone Inzaghi’s men still sit pretty in fifth with 28 points approaching the Christmas period, only four points behind third-placed AC Milan.
Ciro Immobile is their leading goal-scorer with nine goals, but, he’s without a goal in his last four matches for the Eagles, and the Gaffa will be hoping his star forward can break his drought this weekend.
In the fixture last season, Sampordia came out 2-1 winners back in April, but were winless in their previous eight matches prior against Lazio.
Puggioni (GK), Pereira, Silvestre, Skriniar, Regini, Barreto, Torreira, Praet, Fernandes, Quagliarella, Muriel
Marchetti (GK), Basta, Wallace, De Vrij, Radu, Parolo, Biglia, Lulic, Anderson, Immobile, Kishna