Competition: Serie A Date: Sunday 4th December 2016 Venue: Stadio Olimpico Kick-Off: 14:00 GMT
Lazio midfielder Luiz Alberto remains sidelined for the hosts from a torn abductor muscle, along with forward Richard Kishna who is out through injury.
On the plus, Stefan de Vrij and Federico Marchetti are nearing a return following suspected calf and knee injuries, but are likely to make their comebacks next week.
As for Roma, they have been dealt a massive blow ahead of the derby with winger Mohamed Salah out of action for up to three weeks due to an ankle injury.
Diego Perotti is set to spearhead the attack for Giallorossi alongside Edin Dzeko who were both on target in the win over Pescara last week.
Fierce city rivals Lazio and Roma lock horns at the Stadio Olimpico this weekend, in Italy’s famous Derby della Capitale on Sunday afternoon.
It marks the 145th ‘Rome Derby’ between the two sides and the teams come into the match in fine form, both occupying the top four standings in Serie A.
Lazio head into the tie following a 1-0 win away to ten-man Palermo last weekend thanks to a first half strike from Serbian midfielder Sergej Milinkovic-Savic, extending their unbeaten run to nine matches in the league.
Currently, Biancazzurri sit fourth on 28 points trailing their weekend opponents by just a point, and manager Simone Inzaghi is hoping his side can continue their impressive run on Sunday and will be aiming to overtake their neighbours up to second with victory in Rome.
Meanwhile, Roma bounced back from their defeat to Atalanta a fortnight ago with a 3-2 win at home to Pescara last weekend, duly thanks to a brace from Edin Dzeko.
Furthermore, the Giallorossi are the Serie A’s top goal scorers this season and forward Edin Dzeko leads the race for the Golden Boot, topping the chart with 12 goals.
Luciano Spalletti’s men have won their last three meetings against Lazio, including an emphatic 4-1 win last season, and the Sky Blues will be certain underdogs having not tasted victory in their last seven Serie A derbies against Roma.
Strakosha (GK), Basta, Wallace, Radu, Lulic, Parolo, Biglia, Milinkovic-Savic, Felipe Anderson, Immobile, Keita
Szczesny (GK), Rudiger, Manolas, Fazio, Peres, Strootman, De Rossi, Nainggolan, Emerson, Perotti, Dzeko