Empoli right-back Vincent Laurini remains sidelined for the hosts recovering from a muscle strain, whilst midfielder Daniele Croce is a doubt missing last weeks defeat to Fiorentina with a calf injury.
Veteran striker Massimo Maccarone is set to start upfront for Azzurri,who scored a brace in the 4-0 win away to Pescara earlier this month.
Meanwhile, Milan defender Alessandro Romagnoli is unlikely to start at the weekend, following his absence in the Derby de Milano due to a groin injury.
Former Liverpool winger Suso scored twice in the derby, and manager Vicenzo Montella is set to stick with the Spaniard alongside attacking duo MBaye Niang and Carlos Bacco.
AC Milan could leapfrog up to second in Serie A with victory against strugglers Empoli at the Stadio Carlo Castellani on Saturday night.
The Rossoneri head into the match following a 2-2 draw against city rivals Inter Milan in the Derby de Milano at the San Siro last Sunday.
Susos two goals looked to be enough for all three points; however, Nerazzurri snatched a dramatic equaliser during injury-time through Croatian midfielder Ivan Perisic, with honours shared on derby day.
Currently, the result leaves Milan third in the league, but, victory for Vicenzo Montellas side could climb them up to second and within four points of leaders Juventus who travel to Genoa on Sunday.
In contrast, hosts Empoli sit 17th on the table having been outclassed in the 4-0 defeat at home to Fiorentina, which leaves them just three points above the relegation zone.
Despite, smashing four in the win over Pescara a fortnight ago, the Azzurri have struggled to find the back of the net this season, scoring only six times in their last 13 matches.
Milans last two visits to the Castellani have ended in 2-2 draws, but they remain clear cut favourites at the weekend who are unbeaten in their last five meetings against their Saturday opponents.
Skorupski (GK), Veseli, Bellusci, Costa, Pasqual, Krunic, Diousse, Croce, Saponara, Maccarone, Pucciarelli
Donnarumma (GK), Abate, Gomez, Paletta, De Sciglio, Kucka, Locatelli, Bonaventura, Suso, Bacca, Niang