Competition: Premier League Date: Saturday 19th November, 2016 Venue: St. Mary’s Kick Off: 15:00 GMT
Southampton had a host of players away on international duty over the past couple of weeks, and have taken a few knocks.
Goalkeeper Fraser Forster and defender Ryan Bertrand both pulled out of the England squad, as too did Danish midfielder Pierre-Emile Hojbjerg, whilst Serbian attacker Dusan Tadic suffered a broken his nose.
Most, however, are likely to play at the weekend.
As for Liverpool, Adam Lallana is a major doubt after limping off at Wembley, meaning Gigi Wjinaldum should gain a recall to the starting XI.
Brazilian pair, Roberto Firmino and Philippe Coutinho should start despite not arriving back on Merseyside until Thursday – although the latter is doubtful after undertaking a scan shortly after.
Daniel Sturridge will be waiting in the wings.
The Premier League gets a welcome return to the proceedings this weekend after another long, drawn-out international break.
Whilst Man. United vs Arsenal steals the limelight early on, Southampton vs Liverpool is another intriguing affair.
Liverpool, of course, will be looking to remain top of the table, whilst the Saints will want to record their first win in the league since mid-October.
The home side currently sit 10th in midtable but have had some decent results in Europe – most notably a 2-1 win over Italian giants Inter Milan.
That win in the Europa League shows just how far the club has come in recent years but manager Claude Puel will be concerned slightly at their recent league form.
A win here against Liverpool would be most welcome.
Reds boss Jurgen Klopp will feel slightly aggrieved that both Adam Lallana and Countinho returned to Melwood injured but he still has options going forward.
This will be a tough contest on the south coast where his side last season surrendered a two-goal lead to lose 3-2.
Back then, Sadio Mane did the damage for the Saints – bullying the Reds defence. Now Mane is a Liverpool payer – and an improved one at that – Klopp will feel confident enough ahead of this rare 3 O’clock Saturday kick-off for his side.
Such as the competitiveness of the league this year, Liverpool could end the weekend either four points clear at the top or down in fourth place.
This fixture is deemed Liverpool’s toughest (on paper) of this period so dropped points is a big possibility.
Whatever happens though, expect goals.
Forster; Cedric, Fonte, van Dijk, Bertrand; Romeu; Clasie, Davis; Tadic; Redmond, Austin
Karius; Clyne, Lovren, Matip, Milner; Henderson, Can, Wjinaldum; Mane, Coutinho, Firmino
In the last two meetings at St. Mary’s no fewer than 12 goals have been scored (four for Southampton, eight for Liverpool)
Southampton have only won once in the last six meetings – that famous 3-2 comeback last March.
Before that result, Liverpool had won on their last three visits in league and cup competition.
Before joining Liverpool in the summer, Sadio Mane scored four goals for Southampton against the Reds.
Klopp’s side are going for a fifth straight win in the league.
Last year’s 3-2 loss will still haunt Jurgen Klopp and Liverpool so he’ll go all out to make amends.
Southampton like playing the big boys at home so they too will fancy a return to winning ways in the league.
Liverpool, though, will still have just enough this time around to see out a win.