Competition: Serie A Date: Saturday 5th November 2016 Venue: Stadio San Paolo Kick-Off: 19:45 GMT
Napoli defender Raul Albiol remains sidelined for the hosts with a hamstring strain, and winger Dries Mertens is a doubt for the weekend having missed the 1-1 draw to Besiktas on Tuesday through injury.
Maurizio Sarri is likely to start the same attacking trio of Jose Callejon, Lorenzo Insgine and Manolo Gabbiadini in Naples.
Meanwhile, visitors Lazio are without a number of players including centre-backs Stefan De Vrij (Metatarsal fracture) and Bastos (ankle injury).
Ciro Immobile will start at the heart of the attack, after scoring the winner in the 2-1 home win against Sassuolo at the Stadio Olimpico last week.
Napoli returns to Serie A action this weekend, when they play host to fourth placed Lazio at the Stadio San Paolo on Saturday evening.
Maurizio Sarri’s men come into the match following a tough draw against Turkish Champions Besiktas in the group stages on Tuesday night, thanks to a stunning Marek Hamsik strike at the Vodafone Arena to top Group B.
However, domestically the Partenopei suffered a 2-1 defeat to rivals Juventus last weekend with striker Gonzalo Higuain coming back to haunt his former team through a 71st minute winner in Turin.
As a result, it slumps them down to fifth place in the league but they’ll be looking to get back to winning ways and leapfrog their weekend opponents with a victory in Naples.
On the other hand, visitors Lazio head into the weekend in good form unbeaten in their last six matches, including their recent 2-1 home win over Sassuolo, which climbs the Rome outfit up to fourth on the table within one point of a Champions League place.
But, the Biancocelesti know they face a tough ask against a pace attacking Napoli side at home, and manager Simone Inzaghi will be hoping in-form striker Ciro Immobile can continue his rich vein of form, having scored seven goals in his last five matches.
Last season, Napoli did the double over their opponents, including a 5-0 thrashing at the San Paolo, and victory in Rome with goals from Jose Callejon and Gonzalo Higuain.
Reina (GK), Hysaj, Maksimovic, Koulibaly, Ghoulam, Allan, Jorginho, Hamsik, Callejon, Gabbiadini, Mertens
Marchetti (GK), Patric, Wallace, Hoedt, Radu, Milinkovic, Parolo, Lulic, Felipe Anderson, Immobile, Keita
Napoli have won ten of their last 11 Serie A matches at home.
Lazio are undefeated in their last six Serie A matches.