Juventus forward Paulo Dybala remains sidelined for the hosts with a thigh injury, and is joined by winger Marko Pjaca who is ruled out of action due to a foot injury.
Mario Mandzukic is set to keep his place in attack alongside Gonzalo Higuain, who scored the opener during the 4-1 home win over Sampdoria on Wednesday night.
Meanwhile, Napoli striker Manolo Gabbiadini will miss the trip to Turin through suspension, after receiving a straight red during the win over Crotone in midweek.
Lorenzo Insigne and Jorginho could be handed recalls to the starting line-up; however, defender Raul Albiol is still unavailable for Partenopei with a muscle injury.
Two of Italy’s bitter rivals lock horns this weekend, when Juventus host Napoli at the Juventus Stadium on Saturday evening.
The Partenopei were on the brink of their first Scudetto title in 26 years, however, a collapse during the end of last season handed the title to Juventus.
The Naples outfit will be looking to seek revenge in Turin, and they’ll be also facing former teammate Gonzalo Higuain, after swapping allegiance in a big money move over the summer.
Maurizio Sarri’s men head into the match after back-to-back victories against Crotone and followed by Empoli in midweek, and a victory for Napoli this weekend would close the gap to just a point of their weekend rivals.
On the other hand, hosts Juventus suffered a surprise 1-0 defeat to AC Milan a fortnight ago, after a Miralem Pjanic goal was controversially disallowed at the San Siro, resulting in Bianconeri’s second defeat in Serie A.
However, Massimiliano Allegri’s side responded in empathic fashion smashing four past Sampdoria in the 4-1 victory in Turin on Wednesday night, which leaves Juve two points clear of second place Roma.
Last season, Napoli came out on top during a 2-1 win at the Stadio San Paolo including goals from Lorenzo Insgine and Gonzalo Higuain, but in the corresponding fixture back in February the Bianconeri snatched a late winner through a Simone Zaza strike in Turin.
Buffon (GK), Chiellini, Bonucci, Alves, Evra, Pjanic, Marchisio, Khedira, Cuadrado, Mandzukic, Higuain
Reina (GK), Ghoulam, Koulibaly, Chiriches, Hysaj, Hamsik, Jorginho, Allan, Insigne, Mertens, Callejon