Competition: Serie A Date: Wednesday 26th October 2016 Venue: Mapei Stadium Kick-Off: 19:45 BST
Roma striker Edin Dzeko will spearhead the attack for the visiting side, who’s scored four goals in his last three league outings, and was on target in the win over Palermo at the weekend.
Alessandro Florenzi could earn a recall to the starting line-up in place of Juan Jesus, and midfielder Radja Nainggolan is set to keep his spot ahead of Kevin Strootman.
Meanwhile, Sassuolo forward Alessandro Matri will start for the hosts in mid-week, having come on as a substitute to rescue a point late on during the 1-1 draw with Bologna.
Domenico Berardi is still sidelined for the hosts due to a knee injury; however, Simone Missiroli is likely to return to training next week recovering from a muscle strain.
Roma look to make it four straight wins in Serie A, when they take on hosts Sassuolo at the Città del Tricolore on Wednesday night.
Currently, the Giallorossi are second in the table trailing leaders Juventus by just two points, after breezing past strugglers Palermo during a 4-1 win at the Stadio Olimpico.
Luciano Spalletti’s men will want to continue their solid start and post a serious challenge on their Scudetto rivals this year, having finished runners-up during the 2014/15 campaign and third place to Napoli last season.
On the other hand, Sassuolo come into the fixture with just one loss in their last four matches, which sees them placed ninth in the table after their 1-1 draw to Bologna at the weekend.
The Neroverdi have won their last four home matches in all competitions, which included a 3-0 win over La Liga side Athletic Bilboa in the Europa League.
However, the hosts still remain underdogs against their midweek opposition, having lost the last three home ties against Roma at the Tricolore.
Consigli (GK), Peluso, Acerbi, Cannavaro, Lirola, Sensi, Magnanelli, Biondini, Defrel, Ricci, Matri
Szczesny (GK), Florenzi, Fazio, Manolas, Emerson, Paredes, De Rossi, Nainggolan, El Shaarawy, Salah, Dzeko