Competition: Serie A Date: Wednesday 26th October 2016 Venue: Stadio Olimpico Kick-Off: 19:45 BST
Sergej Milinkovic-Savic remains sidelined for the hosts after missing the 2-2 draw against Torino at the weekend with a fractured hand.
Leading scorer Ciro Immobile has six goals to his tally for the Rome outfit, and has scored in his last three successive league matches, including a brace in the 3-0 victory away to Udinese earlier this month.
On the other hand, Cagliari makes the trip to the capital without midfielders Joao Pedro and Diego Farias through injury, whilst Artur Ionita remains out with a calf injury.
Simone Inzaghi’s Lazio take on tenth placed Cagliari at the Stadio Olimpico on Wednesday night, looking to extend their unbeaten run to five matches in Serie A.
The Biancocelesti head into the match following successive league draws, which included a 2-2 draw to Torino at the weekend, conceding a late penalty to deny them all three points.
Inzaghi’s side will be aiming for European qualification this season, and currently as it stands the Rome outfit are sixth on the table, two points adrift of fourth placed Napoli.
Meanwhile, Cagliari’s three match winning streak came to an end during an eight goal thriller in Florence, with Fiorentina securing a 5-3 home victory at the Stadio Artemio Franchi.
Manager Massimo Rastelli is hoping his side can continue their good scoring form, with nine goals in their last four matches heading into this fixture.
Last season, Lazio did the double over Rossoblu in high scoring 4-2 win in Rome and they will be favourites for victory once again, having won seven of the last eight meetings.
Marchetti (GK), Basta, Wallace, Hoedt, Patric, Cataldi, Parolo, Lulic, Anderson, Immobile, Keita
Storari (GK), Pisacane, Salamon, Alves, Murru, Tachtsidis, Isla, Padoin, Di Gennaro, Borriello, Sau