Competition: La Liga Date: Saturday 20th August 2016 Venue: Estadio Nuevo Los Carmenes Kick-Off: 19:15 BST
Guillermo Ochoa is set to start between the sticks for Granada, who have no injury or suspensions to worry about heading into their first game of the new campaign.
Ezequiel Ponce will start in attack, although Argentine striker Paco Jemez, on-loan from Roma, is competing for his spot.
Villarreal have a wealth of injury problems to worry about ahead of the new season, with Jonathan Dos Santos, Roberto Soldado, Cedric Bakambu, Daniele Bonera and Denis Cheryshev all unavailable.
Jaume Costa is a doubt and, if he misses out, Jose Angel will take his spot in defence.
Granada enter the new season in good form, having recently beaten Cordoba and Mallorca in pre-season, but they have a task ahead of them against Champions League hopefuls Villarreal. Granada finished just one point above the relegation zone last term and their aims this year will be to avoid the drop again.
Coming into the game on the back of a 2-1 Champions League Play-Off first-leg defeat to Monaco, Villarreal won’t be feeling fresh heading into their first La Liga match of the season. Having conceded the home advantage in that tie, the Yellow Submarines may sacrifice a strong start to their league campaign in favour of reaching the group stage draw on Thursday.
With the first-leg deficit to think about, and the hangover of a midweek game, Villarreal may be ripe for the taking but the likelihood is Granada don’t quite have the firepower to achieve a victory.
Ochoa, Tito, Agbo, Lomban, Silva, Rico, Krhin, Boga, Marquez, Cuenca, Ponce
Asenjo, Mario, Ruiz, Musacchio, Costa, Soriano, Trigueros, Bruno, Castillejo, Pato, Borre
Villarreal have won the last three matches against Granada.
Granada have won just two of their eight meetings with Villarreal.