Competition: Champions League Play-Off, first-leg Date: Wednesday August 17th 2016 Venue: Stade Louis II Kick-Off: 19:45 BST
Monaco have suffered a double injury blow ahead of the visit to the Estadio El Madrigal, with the absentees of strikers Kylian Mbappe (concussion) and Radamel Falcao (thigh).
Joao Moutinho is set to earn a recall in midweek, alongside fellow Portuguese midfielder Bernardo Silva who scored an 84th minute equalizer in the 2-2 draw to Guingamp at the weekend.
Meanwhile, hosts Villarreal could hand European debuts to new signings Roberto Soriano and Nicola Sansone, signed from Serie A clubs Sampdoria and Sassuolo for a combined fee of £23m.
On the injury front, the yellow submarine remain without forwards Roberto Soldado and Cedric Bakambu through injury, along with Jonathan dos Santos and Denis Cheryshev on the sidelines.
Villarreal prepare for already one of their biggest games of the season, when they host Monaco in the Champions League first leg play-off at the Estadio El Madrigal on Wednesday night.
It’s been somewhat of a disarray for the yellow submarine after the shock resignation of manager Marcelino, who led them to the last four of the Europa League and secured a 4th place finish in La Liga last campaign.
Furthermore, the departures of Alphonse Areola, Eric Bailly and Dennis Suarez has seen a big shift at the club, and with key strikers Roberto Soldado and Cedric Bakambu also out through injury it creates a tough dilemma for new manager Fran Escriba.
The former Getafe man will be urging his players to produce a disciplined performance, in their bid to reach the group stages of the Champions League.
As for Monaco, they head into the play-offs after a disappointing 2-2 draw to Guingamp in their opening Ligue 1 match at the weekend.
Leonardo Jardim knows the importance of this tie and his side will be seeking revenge against Spanish opponents, after being eliminated by Valencia in the Champions League play-offs last season.
Barbosa (GK), Gaspar, Bruno, Bonera, Rukavina, Leiva, Trigueros, Soriano, Castillejo, Samuel, Baptistao
Subasic (GK), Mendy, Jemerson, Glik, Sidibe, Lemar, Moutinho, B Silva, Fabinho, Carrillo, A Traore
After overcoming Fenerbache in the last round, losing away but winning at home, Monaco started their Ligue 1 campaign with a 2-2 draw with Guingamp.
Villarreal are yet to start their domestic campaign but are looking to reach the Champions League for the first-time since the 2008/09 season.